Modeling interlamellar interactions in angle-ply biologic laminates for annulus fibrosus tissue engineering
نویسندگان
چکیده
منابع مشابه
Characterization of a Multi-Laminate Angle-Ply AF Patch for Annulus Fibrosus Repair
Annually, over 5.7 million Americans are diagnosed with two IVD-associated pathologies: IVD herniation (IVDH-a mechanical disruption of the concentric fibrous layers of the annulus fibrosus (AF))) and degeneration (IVDD-a multifactorial process which initiates within the inner gelatinous core (NP), and results in a biochemical degradation of NP tissue), with over 2.7 million requiring surgical ...
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INTRODUCTION Engineering functional replacements for the annulus fibrosus (AF) is contingent upon successful replication of anatomic form and mechanical function. Recently, our group and others have demonstrated the utility of electrospun scaffolds for AF tissue engineering [1]. These ordered, nanofibrous scaffolds direct cell alignment and deposition of a functional fibrocartilage matrix [1]. ...
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Successful engineering of load-bearing tissues requires recapitulation of their complex mechanical functions. Given the intimate relationship between function and form, biomimetic materials that replicate anatomic form are of great interest for tissue engineering applications. However, for complex tissues such as the annulus fibrosus, scaffolds have failed to capture their multi-scale structura...
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Intervertebral disc (IVD) degeneration is the major cause of lower back pain, while the currently available treatments are symptomatic rather than curative. Tissue engineering is a powerful therapeutic strategy that can restore the normal biomechanical motion of the human spine. The ability of a biphasic elastic scaffold to structurally and elastically simulate the annulus fibrosus (AF) tissue ...
متن کاملModeling shear behavior of the annulus fibrosus.
Modeling the mechanical properties of the annulus fibrosus has two distinct challenges: the complex loading state experienced in vivo and the anisotropic, nonlinear nature of the tissue. Previous efforts to model the annulus fibrosus have not considered shear data in the analysis, yet the shear response may be critical to understanding tissue behavior and damage. In this study, we compared four...
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ژورنال
عنوان ژورنال: Biomechanics and Modeling in Mechanobiology
سال: 2011
ISSN: 1617-7959,1617-7940
DOI: 10.1007/s10237-011-0288-0